West Bromwich Albion, Blackburn Rovers, Reading and Liverpool have all booked their places in the last eight of the FA Cup, whilst there are three more ties on Sunday.
Yet the most intriguing tie of the round takes place on Monday night, with Manchester United traveling to Deepdale to take on League One outfit Preston.
The Lilywhites are riding high having won three games in a row in all competitions, and currently lie fourth in the League One table.
Manager Simon Grayson has defeated Manchester United in the FA Cup before having taken his Leeds side - also in League One at the time - to Old Trafford, and came away with a 1-0 win in one of the most famous cup upsets in recent years.
Now, he bids to do it again, this time with Preston - but faces a different manager, with Louis van Gaal in charge rather than Sir Alex Ferguson.
Speaking to The Telegraph, Grayson revealed that he wants to beat the Dutchman - simply because of what he has achieved in the game already.
"Van Gaal is a special manager, who has a worldwide name in the game like Sir Alex," said Grayson. "It makes the hairs on the back of my neck stand up to get the opportunity to pit my wits against him because of his aura and reputation."
"I’m competitive. I want to beat Van Gaal, who’s managed at some of the biggest names in world football, Barcelona, Ajax and Bayern Munich. It’s a fantastic opportunity to try to outdo another manager who has been far more successful than myself," he added.
Manchester United will be hot favourites to win the game, but their mediocre displays in the competition already will give Grayson hope, having seen the Red Devils stumble through games against Yeovil Town and Cambridge United.