Manchester United and Preston North End will do battle on Monday with a place in the quarter-finals of the FA Cup at stake.
Their meeting will pitch Premier League top-four hopefuls into combat with League One promotion contenders, but there has not always been such a gulf in class between the two.
Forty-odd years have passed, though, since they last met in a competitive fixture, while England have won the World Cup since they were last together in the top tier.
There are, however, a number of figures from more modern times to have forged ties between the North West neighbours.
Be that playing or managing, some big names have graced the books at Deepdale and Old Trafford down the years - at various stages of their respective careers.
Here, in pictorial form, we take a look at some of those to have been employed by the Lilywhites and Red Devils, with our gallery including a former England captain, managerial flops, failed academy graduates and the offspring of a legendary coach.