The Gunners defeated Hull City 3-2 in last year's final, and with Chelsea, Manchester City and Tottenham all out of the competition already, they'll be confident of repeating that feat this time around.
It was opponents Middlesbrough who dumped Manchester City out in the fourth round, and Aitor Karanka's men will be hoping to spring another upset on Sunday afternoon.
The game is particularly meaningful for striker Olivier Giroud, who has been with Arsenal for almost three years after his 2012 move from Montpellier.
Yet five years ago, Giroud could have been lining up for Middlesbrough, or even Scottish giants Celtic after admitting to the Arsenal official website that both teams were interested in signing him when he was playing for Tours in France.
"Yes, that’s true," said Giroud. "Middlesbrough and Celtic [also wanted to sign me]. Middlesbrough was a great team… today they are close to coming back into the English Premier League. It will be nice to play against them and it will remind me of my previous years in Tours," he added.
It was reported back in 2010 by the Daily Mail that Giroud had turned down a move to Celtic, and Arsenal fans must be happy that Giroud's career turned out as it has, given that he has hit 47 goals in 112 games for Arsene Wenger's men.