The Hammers’ Spanish shot-stopper will be looking to put in a fine performance and erase the memories of last season’s disappointment in the corresponding fixture.
The Red Devils beat Sam Allardyce’s men 2-0 on that occasion, but it was the manner in which they scored their two goals which will leave Adrian wincing.
Wayne Rooney opened the scoring after just eight minutes, firing in a 45-yard volley which left the 28-year-old helplessly sprawling back to his line and making a real hash of it.
It was a contender for goal of the season, yet in truth it was totally avoidable and the spin completed deceived the Hammers’ number one.
The 32-year-old has been an almost ever-present figure in the Hammers XI since the start of December, but question marks remain whether he has done enough to merit his first-team spot.
Nolan is renowned for his experience, his excellent late runs from midfield, and his ability to take matches by the scruff of the neck and score at crucial times.
However, goals have alluded him of late with his only strike of the season coming in the 2-1 away win at West Bromwich Albion in early December.
Aside from his lack of goals, he has struggled to create in recent weeks and his performance at Anfield last week represented one of a player seriously lacking in confidence. He needs a big match.
West Ham’s left-back has been a revelation in his debut Premier League season after joining the Upton Park outfit from Ipswich Town in the summer of 2014.
Solid, quick, intelligent, strength – all attributes which describe the 25-year-old and ones which could see him land an England cap in the future.
However, his performances in matches against the big clubs this season have left some to suggest he is quite vulnerable – no more so than in last weekend’s encounter at Liverpool.
Direct players such as Raheem Sterling, Adam Lallana and Lazar Markovic caused him all sorts of problems, and he can expect something similar against United duo Antonio Valencia and Angel di Maria.
Cresswell needs a good display against quality opposition, no more than just to remind himself that he has the potential to become a future international player.