The two teams have met once already this season, with United claiming a 2-1 win at Old Trafford thanks to goals from Wayne Rooney and Robin van Persie.
Rooney was also sent off in that game, but he has better memories against the Hammers - most notably last season's fixture at Upton Park.
The Red Devils won 2-0, with Rooney scoring both goals; including a strike from the halfway line, which looped over goalkeeper Adrian and into the net.
Adrian is now faced with the prospect of facing Rooney again this weekend, and told the West Ham United website that he's wary of the skill possessed by the England international after that particular goal.
"Nobody has scored a goal against me from as far out as Wayne Rooney last year, so I need to be careful. It was an amazing goal for him, and you need to be wary of that kind of skill," he said.
29-year-old Rooney has recently been used in a more reserved role by manager van Gaal, with the United skipper mostly playing in midfield now.
With eight goals and four assists this season in the Premier League, Rooney is still having a fine campaign, but with no goals since Boxing Day, the chances of him recreating last season's wonder goal are slim.