Arsenal boss said the Chilean was not close to playing against Aston Villa.
The Gunners cruised to a comfortable 5-0 win over Paul Lambert's woeful side, with Sanchez actually getting a welcome rest.
He missed the game with a hamstring injury, and Arsene Wenger's post-game comments may be slightly concerning to fans with a North London derby against Tottenham only a week away.
Asked at his press conference if Sanchez was close to making the game, Wenger said, reported by Arsenal.com: "He was not very close today."
What does this mean for Arsenal?
Sanchez has a hamstring strain and PremierInjuries.com does not state an expected return date for him.
Arsenal will clearly give him every chance of making a return, but will have to plan without him too, and could not have had a better warm-up than the victory against Villa.
If Sanchez can at least make the bench, having the option of bringing him on as a substitute against a tired Tottenham defence could be an important game-turning moment.
What does this mean for Tottenham?
The uncertainty will provide a bit of a headache for head coach Mauricio Pochettino, who will have to prepare his defence and midfield for two different eventualities.
At least with Sanchez fit and certain to start, they would know they would be playing against him, this time it is less certain how the Gunners will line-up.
Whether he plays or not could have a psychological impact on both sets of players ahead of the game, but seeing Arsenal's big win against Villa will put them under no illusions about Arsenal's danger.