The influential midfielder lasted just 45 minutes on Saturday as the Rams suffered derby defeat to East Midlands rivals Nottingham Forest.
Steve McClaren’s side led at the interval in that contest, but were unable to enjoy the same level of control after the break.
Hughes was unquestionably a big miss, with his composure on the ball helping to make Derby tick.
The Rams have been sweating on his future involvement since seeing him forced off against Forest, but Simpson believes he will come into contention for an FA Cup fourth round clash with Chesterfield.
He told Rams Player: “Will got a kick early on in the game just above his knee and we hope that he’ll be alright to train towards the end of the week.
“We have a few bumps and bruises from Saturday and that’s normal; by the end of the week we hope to have more or less a full quota of players training and preparing for Saturday’s game.”
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Only Craig Forsyth has played more passes than Hughes for Derby this season, helping to highlight how important he is.
His dribbling figures also place the England U21 among the most creative influences at the iPro Stadium, with his game all about getting on the ball and making things happen.