The fixture is of huge importance to Louis van Gaal's side as they have failed to win in their last three Premier League outings, drawing two and losing one.
Neville replied to a question from a follower on his official Twitter account on whether United would triumph against Rangers in London.
It's not really any surprise that Neville is worried when you consider how wretched United's away form in the Premier League has been so far this season.
In the 10 games they have played away from Old Trafford, United have only managed to pick up 12 points in total. Two wins came at Arsenal and Southampton, and of the other eight matches, six have been drawn and two were defeats.
United currently sit fourth in the table, but you have to go down to Swansea City in ninth place to find a team that have performed worse away from home than the Red Devils, who made a number of major signings in the summer transfer window including those of Angel di Maria, Daley Blind and Marcos Rojo.
QPR have only lost twice at home all season and will be hoping for a positive outcome from the match to keep their dream of Premier League survival alive.
What is certain is that United will have to play better than they have in recent fixtures if they want to take all three points at Loftus Road today.