Manchester United went into today's game looking to close the gap on local rivals Manchester City after their draw with Everton on Saturday, and faced a tough home test against fourth placed Southampton.
United may have beaten the Saints just over a year ago, but couldn't repeat the trick as Ronald Koeman triumphed over his long standing rival Louis van Gaal.
The Red Devils were sluggish and seemed to have no attacking gameplan throughout, and could have conceded inside the first 60 seconds as Nathaniel Clyne drove a shot across goal and just wide.
With Falcao not even in the squad, United struggled to make the most out of a number of crosses into the box, and were punished with the opening goal with just 20 minutes to play.
Neat work from Dusan Tadic on the edge of the box led to Graziano Pelle being played through on goal, and whilst the Italian hit the post, the ball cannoned straight back to Tadic, who gleefully tucked away the rebound.
United created a number of chances but couldn't hit the back of the net, with Juan Mata particularly culpable of wasting good goalscoring opportunities.
The Red Devils were left frustrated, but for Southampton, their fairytale season continues, and they jump above United into third place as Koeman's magic shows no sign of ending.