Manchester United are looking to continue their very good home in the Premier League whilst Southampton are looking to get their own back for the defeat their hosts inflicted on them at St Mary's last month.
To be played on Sunday 11th January 2015 at 16:00. Venue: Old Trafford, Manchester
Odds: Man Utd 5/6, Draw 14/5, Southampton 19/5
The winner of this game will end up sitting in third in the Premier League after all of the sides in the division have played 21 games this term. Who thought that would happen in August for Southampton? It is testament to the job Ronald Koeman has done in such a short space of time at St Mary's.
United have not been the best on the road and despite a losing start to the season at Old Trafford, their home form has been near exemplary since as they have put themselves on course to return to the Champions League after only one season out of the competition - despite many injuries troubling the side throughout the campaign.
Having said that, it is expected that Ashley Young is their biggest injury worry ahead of Sunday afternoon's game.
The Saints however had questions about their credentials last month when they lost four consecutive league games after three consecutive difficult fixtures against Manchester City, Arsenal and this weekend's opponents. But recently they managed to get a point against an impressive Chelsea and overcame Arsenal to put them in charge of the final Champions League spot, and within striking distance of United.
Whenever Southampton get written off, they seem to come out and prove a point not so long afterwards. They could also be boosted by the return of their right-back Nathaniel Clyne this weekend. Maya Yoshida is unavailable for the visitors because of participation in the Asian Cup.
“I have to select the best team and also I have to watch the qualities of Southampton, how I can reduce that quality by my line-up but also by our game-plan.”
Louis van Gaal
“We can beat them (United). I believe we can make it very difficult for them. If you analyse them over the last few weeks, you can see that they've grown up.”
Luke Shaw ★ probable ankle
Rafael ★ probable fractured cheekbone
Ashley Young ★★★ out hamstring
Antonio Valencia ★★ questionable groin
Marouane Fellaini ★★ questionable fractured rib
Marcos Rojo ★ probable thigh
Tom Thorpe ★★★ out ankle
Daley Blind ★ probable knee
Sadio Mané ★★★ out thigh
Sam Gallagher ★ probable knee
Nathaniel Clyne ★ probable ankle
Jack Cork ★★★ out ankle
Jay Rodriguez ★★★ out ACL
Jake Hesketh ★★★ out knee