For many sides, a 1-0 reversal on home soil against a fellow title hopeful would be a dagger to the heart of their dreams of lifting the crown.
Branislav Ivanovic’s fine strike for Chelsea at the Etihad Stadium on February 3 saw Jose Mourinho get one over on old adversary Manuel Pellegrini – but Manchester City would have the last laugh.
Manchester City made it past the group stage in the Champions League for the first time in 2013/14, but their involvement in Europe’s premier club competition was ended in the last-16.
Barcelona proved too strong in the second round, with Lionel Messi and Dani Alves netting home and away for the La Liga giants as they progressed 4-1 on aggregate.
Wigan Athletic stunned Manchester City in the 2013 FA Cup final, and they repeated the trick in the quarter-finals of the 2014 event.
Few gave the Latics much hope as they prepared to visit the Etihad Stadium in March, but the Championship giant-killers prevailed 2-1 courtesy of goals from Jordi Gomez and James Perch.
Manchester City were hoping to make a flying start to the 2014/15 campaign, but fluffed their lines in the traditional curtain-raiser to the season at Wembley Stadium.
Manuel Pellegrini saw his Premier League champions crushed 3-0 by FA Cup holders Arsenal in the Community Shield, with Santi Cazorla, Aaron Ramsey and Olivier Giroud securing more silverware for the Gunners.
Potters go potty
Stoke City had suffered 12 straight defeats at Manchester City prior to a top-flight contest at the Etihad Stadium on August 30.
History was to be made, though, by Mark Hughes’ men as they picked up their first Premier League victory in that part of the world – with Mame Biram Diouf’s fine solo effort securing a shock 1-0 win.
Left on the brink
Manchester City’s Champions League frustrations boiled over on a night to forget against CSKA Moscow, with their European dreams left hanging by a thread following a 2-1 defeat.
Yaya Toure and Fernandinho saw red, and Seydou Doumbia bagged a brace, to leave Manuel Pellegrini’s men with it all to do in their bid to reach the last-16.