The Besiktas attacker has been in good form but coach Alain Giresse has opted for other options ahead of the competition in Equatorial Guinea.
The Besiktas forward has been in strong form of late, netting eight Super Lig goals this term, but has been overlooked by national coach Alain Giresse.
Ba’s absence means that the goalscoring burden will have to be taken up by Premier League forwards Diafro Sakho, Papiss Cisse and Mame Biram Diouf.
Senegal are set to take on Ghana, Algeria and South Africa in Group C of the tournament in Equatorial Guinea next month.
Senegal’s preliminary AFCON squad:
Goalkeepers: Pape Demba Camara (Sochaux), Bouna Coundoul (Ethnikos Achnas), Lys Gomis (Trappani), Ousmane Mane (Diambars)
Defenders: Papy Djilobodji (Nantes), Boukary Drame (Atalanta), Lamine Gassama (Lorient), Ibrahima Mbaye (Inter), Cheikh Mbengue (Rennes), Kara Mbodj (Genk), Lamine Sane (Bordeaux), Pape Ndiaye Souare (Lille), Zargo Toure (Le Havre)
Midfielders: Stephane Badji (Brann), Pape Kouli Diop (Levante), Idrissa Gana Gueye (Lille), Cheikhou Kouyate (West Ham), Alfred Ndiaye (Real Betis), Pape Alioune Ndiaye (Bodo Glimt), Salif Sane (Hanover)
Strikers: Papiss Cisse (Newcastle United), Mame Biram Diouf (Stoke City), Moussa Konate (Sion), Sadio Mane (Southampton), Dame Ndoye (Lokomotiv Moscow), Henri Saivet (Bordeaux), Diafra Sakho (West Ham), Moussa Sow (Fenerbahce)