Manchester United: De Gea, Jones, McNair, Evans, Valencia, Carrick, Rooney, Mata, Young, van Persie, Falcao
Subs: Lindegaard, Rafael, Smalling, Blackett, Fletcher, A.Pereira, Wilson
Newcastle United: Alnwick; Janmaat, Coloccini (c), S.Taylor, Dummett; Colback, Anita; Sissoko, Perez, Gouffran; Armstrong
Subs: Woodman, Williamson, Satka, Cabella, Vuckic, Riviere, Cisse
Manchester United boss Louis van Gaal will be keen for his team to react to seeing their winning run ended by Aston Villa in their last game.
United may have still secured a point from that game, but van Gaal will want to get back to winning ways with his team chasing Manchester City and Chelsea at the top of the league.
As has been the case for most of the season, United have had several injuries to contend with in the build up to this game, which has given the Dutchman a few selection headaches.
Newcastle will be determined to react to the heartbreak of a late defeat in the derby game against Sunderland.
Alan Pardew has been vocal in his belief that his team are good enough to secure a European place by the end of the season and it’s now time for them to show it.