Both defenders were at Southampton last season and have since gone on to make the England squad - all thanks to the opportunity the now Spurs boss gave them when he was in charge at St Mary's.
But Pochettino didn't have to promote Chambers, now at Arsenal, or persist with Clyne - he could have signed a new right-back.
Instead, the Tottenham manager gave them a big opportunity to impress - one they both duly took.
"At Southampton, we always wanted to give young players a chance to play. A good example was in my last pre-season there, when we considered signing a right-back," Pochettino told reporters.
“We already had Nathaniel Clyne and we were considering another. But we decided to take Calum Chambers from the academy on pre-season because we wanted to give him an opportunity.
"Now, a couple of years later, they are both in the England squad. It is our job to bring through young players and it is fantastic when it happens."
Clyne is still at Southampton - and performing impressively - while Chambers has made an encouraging start to life at Arsenal. Now to find Tottenham's next top talent.