Lovren was substituted at half-time during the 3-1 win over Bournemouth in the League Cup in midweek.
Lovren missing out could mean a first start for Mamadou Sakho since September after he replaced the Croatia international for the second half of Wednesday night's game.
The Reds adopted a back three during the win over Bournemouth - with Kolo Toure and Martin Skrtel completing the three. The other option for Rodgers would be to revert to back four with Javier Manquillo and Alberto Moreno coming into the side.
Liverpool will also be without Mario Balotelli who has recently been banned for one game for a social media post, something which Brendan Rodgers accepts.
He again praised Raheem Sterling, who is likely to lead the line again on Sunday.
Rodgers told reporters: "Sterling had a great performance the other night in a difficult game."
It was confirmed that Brad Jones will keep his place in the side after replacing Simon Mignolet in goal for the past two games, despite a poor error that led to Bournemouth grabbing a consolation in midweek. The omission of Mignolet for an 'indefinite' period has been one of the major talking points.