Manchester City loanee and former West Brom man also features.
Here are five players to watch, with several of who have previous Premier League connections:
Italian striker Giuseppe Rossi is a key player when fit, but that's been his big issue over the past few seasons. His latest lay-off saw him go down with another knee injury in September, and was projected to be out for five months. This would make featuring in the clash with Tottenham possible for the former Manchester United youngster providing there are not setbacks. Last season he scored 17 goals in 24 games.
Rafa Benitez's last folly in the transfer market, Alberto Aquilani never looked like succeeding at Liverpool. He has rebuilt his career at Fiorentina, but is not having the best of seasons this time around. He has just one goals and one assists as clouds gather over a potential contract renewal. Last season he scored six goals for the club.
Fiorentina's prized asset, the Italians fought off interest from Manchester United and Barcelona to hold onto the Colombian. Rated at around £40 million in the summer, the World Cup star is a huge threat and will give Tottenham's full-backs a real test. He has three goals and three assists this season.
Borja Valero didn't show his best form at West Brom, but he has been sensational since joining Fiorentina. The creative midfielder is a valuable and experienced member of the side who has two goals and two assists this season. In 2013/14 the former Real Madrid youngster scored seven goals and provided 11 assists.
On loan from Manchester City, Micah Richards knows Tottenham well - and often landed up on the winning side against them. He's been far from a regular since moving to Italy but he could be granted a key role in the matches due to his experience against Tottenham.
Also notable: David Pizarro and Stefan Savic (Formerly of Manchester City), Marcos Alonso (Formerly of Bolton and Sunderland), Mario Gomez.