Match to be played on Monday 8th December 2014 at 20:00. Venue: St. Mary's Stadium, Southampton.
The Red Devils have gained some momentum after struggling for consistency in the opening weeks of the season and are looking good for a top-four finish.
Heading into this weekend’s round of matches, United found themselves fourth in the Premier League table with 25 points from 14 games.
Meanwhile, Southampton’s credentials for a top-four finish have taken a blow as they have lost their last two fixtures.
Following a 3-0 home defeat to defending English champions Manchester United last weekend, the Saints went down 1-0 to Arsenal in London in midweek.
Southampton: Forster; Clyne, Fonte, Yoshida, Bertrand; S Davis, Wanyama, Reed; Long, Pelle, Mane
Manchester United: De Gea; Valencia, Smalling, Rojo, Young; Herrera, Carrick, Fellaini; Rooney; Van Persie, Wilson