1 - Southampton have scored the first goal in four of their last five Premier League meetings with Manchester United but lost three and won none of those four matches.
The Red Devils have won nine and lost just one of the last 12 Premier League games against their Monday night opponents.
2 - The Saints have started the fewest spread of players this season in the top flight (15), while Manchester United have handed starts to more players than any other team (26).
Louis van Gaal's side have used a league-high 31 players this season, with David de Gea the only player to feature in all 14 games.
|David de Gea||Man Utd||14||1,260|
3 - Wayne Rooney has scored five goals in five Premier League starts against Southampton, while Robin van Persie has scored five goals in his last six appearances games against the Saints. After a spell sidelined through injury, Rooney is expected to make his return on Monday.
4 - Nathaniel Clyne has made more tackles than any other Premier League player this season (64). The England full-back is also in the top 20 for the most sprints made so far this season. Against Arsenal in midweek, Clyne made more sprints (67) than any other Southampton player.
5 - United look to become only the second team this season to record five back-to-back wins, alongside Newcastle United. The Red Devils will be looking to make the long trip down to the South coast worthwhile with a victory that would see them leapfrog their opponents.