Manager Alan Pardew has said he doesn't know whether he'll be fit enough to face the league leaders.
Alan Pardew's side are in the midst of an injury crisis with as many as 10 first team players sidelined, and any player returning would be a welcome boost to the side, but the Newcastle boss stressed he doesn't know if Coloccini will be able to play against this season's pace setters.
He told his pre-match press conference: "Fabricio Coloccini has been training today but whether he has the fitness levels to play in this game, I don't know."
Last season, Newcastle managed to stun Jose Mourinho's side with a 2-0 victory, which included a goal from Loic Remy, who has since joined the Blues.
Newcastle endured a retched start to the season before going on a winning run which lifted them to within touching distance of the Champions League places.
The Magpies currently sit in 10th place in the Premier League table after losing at West Ham and drawing against Burnley but Pardew says the confidence is high within the camp.
"Mentally we are in a strong position and our confidence is high. We have good spirit and are learning lessons along the way."
Chelsea are currently on a club record unbeaten run and have only dropped six points in the Premier League this season by drawing on three occasions on the road, but Pardew seems confident they will lose a game at some stage this season, and hopes it will be his side that capitalises.
He added: "We need to threaten Chelsea because they look terrific. They are a great team who are strong and organised.
"Somewhere along the line Chelsea will slip up, and hopefully we can exploit any weaknesses they have."