The ex-Gunner feels Ronald Koeman's side are better equipped to make the top four than his former club or Brendan Rodgers' Liverpool.
The 26-year-old, who also turned out for Birmingham City and Bolton Wanderers and retired early due to health concerns, predicted his top four and left both Arsene Wenger and Brendan Rodgers' sides out.
When asked to predict his top four for the season during a Sportlobster Q + A, Muamba said: "Chelsea, Utd, City, Southampton. In that order."
Chelsea currently top the Premier League table, with Manchester City six points behind them in second.
Southampton, who were previously second before they lost to Manchester City at the weekend, are a point further back in third but face Arsenal at the Emirates Stadium later tonight.
The Gunners can close the gap on them to just three points, while Manchester United's recent winning run already puts them just a point behind the Saints.
Liverpool, meanwhile, are eighth, six points behind Southampton after registering two wins on the trot.