The pair helped Spurs as they put in their finest performance of the campaign to date against Everton on Sunday, and Pochettino must stick by them.
Tottenham beat the Toffees 2-1 and while the more attacking members of the squad will steal most of the acclaim, Bentaleb and Mason's partnership was a major reason behind their success.
Bentaleb's tenacity and Mason's technical ability are perfectly suited to compliment each-other and it looked the most cohesive partnership that Spurs have deployed so far.
Pochettino has not settled on a midfield pairing, with a number of options being tested to limited effect, but he needs to stick with his two academy products for the foreseeable future after their displays against Everton.
The Argentine boss has spoken of his desire to trust the club's youngsters and with Mason and Bentaleb he has the perfect chance to prove that he is true to his word.
Although both are inexperienced, they look to be a midfield axis which could be utilised by Spurs for many years and their development will be aided by playing consistently for a season.
There may be matches where they are exposed, as there are still weaknesses in both players' games, but they are still the most exciting two options Pochettino has at his disposal.
Their energy and desire is also something which fits perfectly with his chosen style of play and having the duo accompanying Harry Kane in the starting line-up is sure to be a positive signal to give to the White Hart Lane faithful.
Spurs's youth academy has not been as productive as many would have hoped in recent times, but an exciting crop of talent appears to be breaking through at the moment and Pochettino should let it form the core of his team as they look to progress.