The five-time Premier League winner has found it difficult to adjust his game to suit the style that the Serie A demands and due to his lofty reputation, he has been put under the media microscope.
Under former manager Walter Mazzarri, he played at the centre of a central defensive three but struggled to look comfortable. Following his appointment, Mancini opted for a 4-4-2 formation, with two central defenders, however, decided to leave Vidic on the bench for his first game in charge.
In the pre-match press conference in the build up to their Europa League game with Dnipro on Thursday, the 49-year-old was confronted over Vidic's form and asked what he thought the reason was.
''I've known him since the two of us were in Manchester and I'm sure he'll be useful to us,'' Mancini was quoted as saying in Goal.
''It's quite normal to encounter difficulties coming here because Italian football is totally different to the Premier League.''
The list of players who have gone on to fail having made the move between Serie A and the Premier League is substantial. In this past transfer window alone, Ashley Cole, Fernando Torres and Nemanja Vidic have made the move to Italy only to be hung out to dry in the press. Similarly, the handful of arrivals from Italy to the Premier League have failed to pull up any trees either.
Although Vidic has been linked with a swift move back to Manchester United in recent weeks, it would be a surprise to see Louis van Gaal opt to offer the experience Serbian a deal, even if only for a short time.
The move has proven challenging for Vidic but as a player that has proven himself on many different stages in world football, it will also be one he will relish.