Arsenal manager Arsene Wenger has confirmed that Wojciech Szczesny, Theo Walcott and Jack Wilshere are all out of the side's Champions League tie with Borussia Dortmund on Wednesday night.
Szczesny and Wilshere both had to be substituted off against Manchester United at the weekend and they have not recovered in time to play a part in the Gunners' midweek Champions League fixture.
In better news for the side Danny Welbeck will be available for selection, but Walcott is set to miss out.
Arsenal FC (@Arsenal) November 25, 2014
Wenger has come under pressure after the side have made their worst start in the league for 32 years.
Arsenal have won just four of their opening 12 Premier League matches and they know that a massive improvement is needed domestically.
In European competition, too, their form has been less than convincing. The London outfit look set to qualify from their group, but they have looked short of quality in their opening fixtures in Europe's premier competition.
It means that the pressure is mounting on Wenger and he can ill-afford another loss to Jurgen Klopp's men on Wednesday night.
It promises to be a tense atmosphere at the Emirates Stadium, but the experienced French boss has urged the supporters to be patient with his side.
"I've shown I can take criticism in the 18 years I have been here," he said at a press conference today. "Everyone has the right to an opinion. We must show solidarity.
"There's a very strong bond inside the team and inside the club. We will have a very strong season. I believe in what I do and I believe in my players, their quality and their spirit."
Dortmund hammered Arsenal the last time the two teams met and exposed their deficiency in defensive midfield.
The German side created chance after chance against Wenger's side, with their attacking movement particularly eye-catching.
It was a display which showed how far Arsenal still have to go to be a match for the top teams across the continent, but Wenger actually thinks that his side are well placed to get the three points against Dortmund this time around.
"It's an important game for us and we have a good dynamic in the team which gives us a good chance against Dortmund," he concluded.