Match to be played on Monday 24th November 2014 at 20:00. Venue: Villa Park, Birmingham.
Ronald Koeman’s side have been the surprise package so far this season and will be favourites to win against the Villans.
On the other hand, Villa are struggling in the bottom half of the table and are currently 16th in the standings with 11 points, just two points above the bottom three.
Hosts Villa will be without defender Philippe Senderos for a month with a calf injury, while Ron Vlaar is sidelined with a similar problem and Nathan Baker has a knee issue.
Meanwhile, Southampton boss Koeman has a slight worry over the fitness of French midfielder Morgan Schneiderlin, who has a groin problem. Steven Davis is also doubtful, but Dusan Tadic seems to have recovered.
Aston Villa: Guzan; Hutton, Okore, Clark, Cissokho; Westwood, Sanchez, Cleverley; N’Zogbia, Agbonlahor, Weimann
Southampton: Forster; Clyne, Fonte, Alderweireld, Bertrand; Cork, Wanyama, Schneiderlin; Tadic, Pelle, Mane