But he was on the losing side as Uruguay defeated the Arsenal star's home nation.
Arsenal fans have not taken long to fall in love with Alexis Sanchez. The Chilean has been banging in the goals since arriving in North London, becoming an instant fan favourite in the process.
Of course Arsenal fans knew what to expect from watching Alexis excel with both Barcelona and in particular the Chilean national team. This international break has been no different.
The Arsenal man scored a header against Venezuela at the weekend and was on the score-sheet again last night as Chile took on Uruguay.
Again Sanchez found the back of the net with a header, a surprising asset many Arsenal fans did not know he had in his locker. He gave Chile the lead on the half-hour mark to rapturous applause from the boisterous home support.
However, just like his recent time with Arsenal, it did not end well. Like against Anderlecht and Swansea he ended up on the wrong side of a comeback. Uruguay scored through Diego Rolan and Alvaro Gonzalez to seal victory.
However, Alexis has now taken his scoring record on even further. Arsenal fans will hope that is the trend that continues against Manchester United this weekend.