Derby County forward Chris Martin is likely to get the nod for the England game following an ankle injury to Steven Fletcher.
The Sunderland striker was was brought off early into the second-half against Ireland after going over on his ankle and now his replacement in the match, Chris Martin, looks likely to get the nod for his first start in a Scotland shirt.
Talking ahead of the game, Strachan said: ''One or two might need rested, while Steven Fletcher is away home to get a scan on his ankle.
'David Marshall has a bit of a groin strain. He was fantastic but changing keeper has to be a thought. We might try a different shape but we have to go on and win it. Everyone in the squad would like to play but winning is the priority.'
On the strikers situation, Strachan added: 'It would be nice to see Stevie [May] somewhere along the line. And, Chris [Martin], I watched him in last week's 5-0 win for Derby and he was terrific.'
After replacing the injured Fletcher during Scotland's crucial qualifying win on Friday night, it is most likely to be Martin that gets the nod over his Derby County teammate Johnny Russell and Sheffield Wednesday striker Stevie May.
However, since it's a friendly and played in friendly conditions, all three players could get a chance on the pitch at some point during the game.
Chris Martin, Johnny Russell and Stevie May join Everton striker Steven Naismith as Strachan's attacking options and with just four goals and 37 caps between them - of which four goals and 33 caps are Naismith's - then the former Celtic manager will be praying to see one or two of his strikers opening their account against the Auld Enemy.
Strachan will also have Derby midfielder Craig Bryson available, after missing the qualifying match with Ireland through injury, as he looks to mastermind the plan to conquer England on home soil.