The Tottenham centre back will come up against his former White Hart Lane teammate in Brussels on Sunday.
Jan Vertonghen's first season in the Premier League turned out to be Gareth Bale's last at Spurs, and unsurprisingly, there are few that have as firsthand knowledge of the Real Madrid star as the 27-year-old.
But the former Ajax man has a few ideas about how team's can repel the threat of Bale, with an emphasis being on defending against the player as a group rather than individually, especially important if Vertonghen starts at left back and in direct opposition to Bale on the Wales' right wing.
"He's an unbelievable player. I'm looking forward to playing against him," said the defender.
"He's one of the best in the world but you can't be scared playing against good players.
"It's very difficult to mark him. Defenders can't mark him one-on-one, so we have to defend him as a team."
Though not deemed adequate enough to be Spurs captain, it is believed Vertonghen will lead Belgium out against Wales should, as expected, Vincent Kompany fail to feature.
With Wales currently topping the group above the Belgians, Vertonghen sees similarities between the way Chris Coleman's side have improved the fortunes in recent years, and the way in which Belgium have grown into one of the continent's top national teams.
"Wales are top of the group and they deserve to be there," said Vertonghen.
"Wales are in the position we were in for a couple of years. It's a nice position because no-one expects big things from you but you're able to do it.
"I expect Wales to have a very strong team in the next couple of years."