Rosler led Wigan to the FA Cup semi-final last season but his side have struggled this term, and it appears the former Manchester City favourite has paid the price.
Rosler succeeded Owen Coyle at the DW Stadium after the former Bolton Wanderers manager endured a difficult start to the season when he succeeded Roberto Martinez, following the club's relegation from the Premier League.
After a season where he led the Latics to the FA Cup semi-final, where they were beaten after extra time by eventual winners Arsenal, and to the play-off places, Rosler has paid the price for a poor start to the season which has left Wigan in a perilous situation, where they sit a point from safety in the relegation zone from the Championship.
Rosler's last game in charge was the 3-1 defeat to Bolton Wanderers last Friday, and assistant manager Graham Barrow will take charge of first team affairs.
Chairman Dave Whelan told the club's website: “I have thought long and hard about this. I have thought about little else for days in fact. Initially my thoughts were that Uwe should be given more time. He is a good manager and I like him immensely as a person, he is honest, passionate and clearly works day and night to try and earn success for the team.
“Following the incredible achievements of last season, I felt it was the right thing to do that he should be given more time. However, the situation we find ourselves in at the moment, and the run of results in recent months, really has been alarming. Something is clearly not working. For whatever reason, the team is not gelling, despite substantial financial backing in the summer and the dressing room being blessed with a huge amount of quality.
“Therefore, I have now come to the reluctant conclusion that for the long term good of the club, we need a change.
“Uwe is a good man and a good manager and he will bounce back, I am sure of that. We thank him for his efforts with us, I could not have wished to appoint a more committed and hard-working manager and we sincerely wish him all the best in his future career."
Wigan have only won three league games so far this season and it seems a far cry from last season when a terrific run under Rosler took them to Wembley once again, where they beat Manchester City in the quarter-finals of the competition, and into the play-offs, only for them to be denied by eventual winners QPR.
Given the lengthy period that Wigan spent in the Premier League prior to the reigns of Coyle and Rosler at the DW Stadium, and the backing that Whelan thinks he has given the club, the next manager will have to show signs that the club can compete well in the Championship for the remainder of the season, and aim to regain their place in the Premier League in the medium term.