The Spurs man arrived to training with the national side with an ankle knock, and hasn't been able to train all week with his England teammates.
As a result he has returned to his club for further treament on the injury.
It represents a bit of a setback for the winger as he hasn't been part of Mauricio Pochettino's preferred starting XI for much of the season, though he has seen some game time in both the Europa League and League Cup games.
The 23-year-old has so far made a total of 13 appearances for Spurs in all competitions this season, scoring two goals - and was selected in the previous England squad by Roy Hodgson to face San Marino and Estonia - and managed to get himself on the scoresheet against San Marino.
Townsend may not have been a first choice for England given Roy Hodgson's recent use oof the 4-4-2 diamond formation, but could have been used from the substitutes bench, and with Hodgson seemingly a fan of the winger, it was more than likely he will have been given a run out.
It would have been another chance for Townsend to impress from afar, but this latest minor knock has curtailed that particular chance.
After impressing at the start of last season, Townsend has struggled to make much of an impact for his club because of a series of injuries. His lack of starts in the Premier League this season has done nothing to dampen speculation with a move away from White Hart Lane this term.