The Chelsea midfielder had played with a hamstring injury during the weekend's win over Liverpool.
Chelsea manager Jose Mourinho said Fabregas played with a problem during the 2-1 win against Liverpool at Anfield on Saturday.
The Blues will be hoping that Fabregas will be available for the Premier League clash with West Bromwich Albion at Stamford Bridge on November 22 following the break.
There were reports suggesting that the summer signing from Barcelona could be out for up to three weeks following the weekend's win, which would be a massive blow to the side given the catalogue of assists he has brought to the team so far this season.
If those reports were to be true, he would miss the Baggies' visit to West London, and could miss the Champions League trip to Germany to take on Roberto Di Matteo's Schalke, and even a trip to Sunderland the following Saturday in the Premier League.
Fabregas isn't the only member of the Premier League leaders who will miss out during Spain's internationals. Striker Diego Costa was omitted from the Spain squad as he tries to get fit following problems with his hamstring and his pelvis after missing four competitive games following the last international break.