Schurrle has had problems with illness for much of the season so far, which has limited his opportunities in the first team at Stamford Bridge this term.
The forward misses a qualifier against Gibraltar and a friendly against Spain.
A statement from the German national side said: “Schurrle suffered a persistent infection in October and could not train regularly.
“It was agreed with coach Joachim Loew that he stays in London and trains individually to optimise his fitness.”
Schurrle remains at Chelsea for the international programme along with Cesc Fabregas and Diego Costa, who were left out and withdrawn from the Spain squad respectively.
The 24-year-old has made a total of 12 appearances in all competitions so far this season for the Blues, with half of his eight Premier League appearances so far this season coming from the substitutes bench.
The news represents a blow for his country as they look to overcome a difficult start to their Euro 2016 Group, having picked up just the four points from their opening three games in Group D.
Schurrle is undoubtedly a talented player that has been used effectively by both club and country, but if they want to get the best out of him, then they want him to be at his fittest.