Bojan Krkic opened the scoring with a fine individual effort, before Jonathan Walters doubled Stoke's lead.
Spurs then had Kyle Naughton sent off late on and the away side held on for a victory that takes them up to ninth in the Premier League.
"I was really pleased with the manner of the performance," Stoke boss Mark Hughes told BBC Sport after the game.
"We had a game plan and executed it to the letter. We were always a threat, we had a good shape about us, when we had the ball we broke with pace and precision and scored two goals as a consequence. We are where we expected to be after these games so we are progressing well."
Meanwhile, goalkeeper Asmir Begovic - who has interestingly been linked with Liverpool once again recently - took to Twitter to express his delight. So did goalscorer Krkic and winger Victor Moses.
Huge win for us today! Fantastic effort by all. Great support by the fans, safe trip back! Onto international duty now! #potternation— Asmir Begovic (@asmir1) November 9, 2014
YEEEEEESSS!!!!!! Well deserved victory vs Tottenham, amazing performance of the team in a very difficult stadium! Up the Potters!! #SCFC— Bojan Krkic (@BoKrkic) November 9, 2014
Great win at a tough ground the boys were superb! Appreciate all of your support as always http://t.co/8u4fgMm4Vn— Victor Moses (@VictorMoses) November 9, 2014
And Stoke striker Peter Crouch (an unused substitute) also tweeted, thanking the Tottenham support for their reception. Spurs fans were welcoming the 33-year-old back to White Hart Lane in light of his previous two-year spell at the club.