Radamel Falcao is not part of the Colombia squad for upcoming games against the USA and Slovenia.
When United snapped up the player in the summer for some it was seen as a master stroke. Brought in on a loan spell from AS Monaco and still recognised as one of the greatest strikers in the world, of course it was a good deal.
Others were wary. Falcao had been out of action for a long time because of a knee injury. Having suffered similar problems earlier in his career, the concern had merit.
But he certainly looked in good enough shape early into his United career - until the first problems arose. He suffered with jet-lag after returning from international duty with Colombia. Then it was reported he had picked up a knock before the Chelsea game - missing that and the Manchester derby game in succession.
Now it is confirmed he is out of action for the weekend tie against Crystal Palace - with his injury still shrouded in a cloak of mystery.
It is reported he has a 'knock to his calf' but it must be more severe then that. Louis van Gaal even confirmed last night that his return date was open ended.
Those worries will be exacerbated by the news that Falcao is not in the Colombia squad announced in the early hours of the morning. Jose Pekerman has left the star striker at home, despite his heroic return to action last month. Instead young pretender Yimmi Chara of Deportes Tolima is called up to the squad.
Falcao's injury problems are already starting to cause debate among Manchester United fans, but football fans in general will certainly hope he pulls through his latest mishap.
United or not Falcao is a gifted footballer whose recent injury problems are a real disappointment for the game.
So hopefully he will be back playing for Colombia and United very soon.