Skrtel was pleased with the Belgian following his performance against Real Madrid in the Champions League in midweek.
Mignolet pulled off a series of outstanding saves during the Reds' Champions League Group B game but he was powerless to prevent Karim Benzema's strike midway through the first half, as the Reds put in a spirited performance.
Skrtel told the club's website: "When you play against Real Madrid, they always create chances and you need your 'keeper to perform well. That was the case. Simon did really well, made some crucial saves and really helped us in the game."
Mignolet has been under fire for much of his Anfield career. His ability to pull off an outstanding save has not been questioned, but commanding his area and communication with his back four has been a problem for the Reds as they look to tighten up at the back following on from last season.
The defence as a whole has been under fire with the Reds only keeping two clean sheets in all competitions so far this season.
He said: "When you're conceding goals and not keeping clean sheets, the back four and 'keeper are always the first to be blamed and criticised.
"It's easy to criticise the back four and 'keeper, but it's fair to say we are defending as a team and attacking as a team; it's not only about the back four and the 'keeper.
"But we know what we're doing wrong and where we made mistakes so we'll try to improve for the future, try to play better in defence and try to score more goals as well."
A lot of work has been put into Liverpool trying to tighten up at the back but there are still several individual errors that are letting the side down, and the lack of goals from the team doesn't help results.
What Brendan Rodgers wants to see is more clean sheets and fewer errors from his side going forward, and this weekend they face a stern test in the form of Chelsea. It would be a good time to put in their best defensive display of the campaign and get a clean sheet. They'd hope a goal would come at the other end in order to kick-start their season, and calm any fears that they will miss out on the Champions League places, for now.