Jose Mourinho's side travel to Anfield to face the Reds in a crunch Premier League clash this weekend, with both sides having failed to win in the Champions League earlier this week.
The Blues, though, are unbeaten so far this season and Liverpool face a tough task containing the league leaders.
But Keown believes star striker Sturridge could provide a massive boost in confidence for Brendan Rodgers' side if he is fit to face Chelsea on Merseyside.
"If they now win against Chelsea he [Rodgers] will be able to justify his choices. But they have to show the kind of performance we haven’t seen so far this season," Keown said in a 'Tackle Keown' session on the Daily Mail website.
"I’m intrigued to see which players he uses from the [Real] Madrid game because I think there will be one or two nervous players who have not been nailed on in their performances so far.
"If Daniel Sturridge is back, he will give them so much confidence and he could be the difference."
The fact that the 25-year-old is touch and go for the Anfield clash also suggests Liverpool could hold the key of keeping Mourinho guessing until game-time. Kick-off is at 12.45pm UK time on Saturday.
However, the Liverpool Echo report that Sturridge will not be fit in time for the match.