Paul Lambert gave an injury update to Sky Sports News ahead of the side's Premier League encounter with Tottenham on Sunday at an open training session at Villa Park
Hutton has an ankle problem whilst Senderos still has a thigh injury as Villa look to put behind them a difficult spell of five consecutive Premier League defeats, and recapture the form at the start of the season which saw them take 10 points from their opening four games.
He told Sky Sports News: "Alan is still struggling with his ankle at the minute, Philippe is struggling with his thigh strain. [Nathan] Baker will hopefully be back, [Andreas] Weimann's not here again but will be back for Sunday, so there's one or two coming back."
Lambert was also asked about when illness plagued the side earlier on in the season ahead of a 3-0 defeat to Arsenal.
He said: "I've encountered that situation before, the illness thing but injuries happen, they're part and parcel of the game."
The Villa boss is anticipating a tough encounter this weekend when Mauricio Pochettino brings his side to Villa Park, a side that is also desperate to get their league campaign kick-started, having only won the three games in the league so far this season under their new boss.
Lambert added: "I thought Tottenham were a good team last year and it's not change my opinion. It should be a hard game, they're one of the top sides but we're at home and we have to put a show on."