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Louis van Gaal's side travel to the Etihad Stadium for the first Manchester derby of the season at the weekend, where they will face a Manchester City side that have lost their last two games in all competitions.
And Rooney, who was previously suspended, is now eligible for the clash.
Despite Man United's strong performance without the skipper against Chelsea, however, Cole feels his return is perfect for Van Gaal this Sunday.
"He has got to be raring to go," Cole is quoted as saying by the Daily Mail.
"He is a professional footballer. When you miss games through injury or illness or suspension, you are going to be disappointed.
"I have no doubt he will be chomping at the bit now and ready to go having missed three games.
"It's going to be a massive boost to have a player of his quality back. Hopefully we can go to Man City and get a positive result."