Derby v Chelsea
Tottenham v Newcastle
Bournemouth v Liverpool
Sheffield United v Southampton
Tottenham and Newcastle is the only all-Premier League tie, with Alan Pardew's side knocking out Manchester City earlier on Wednesday evening. Newcastle beat Spurs only days earlier, 2-1.
Chelsea and Liverpool face Championship opposition in Derby County and Bournemouth, with both facing potentially tricky away ties.
In form Southampton travel to cup specialists Sheffield United, who reached the semi-finals of the FA Cup last season.