Manchester United follow up their draw with Chelsea with a visit to Manchester City this coming weekend.
City themselves are looking to bounce back from a disappointing loss to West Ham, but are four points ahead of United.
The Red Devils welcome back Wayne Rooney from suspension, while Radamel Falcao is also likely to be fit again.
It's possible both start, but at the very least, it's fair to assume at least one will feature alongside Robin van Persie in Louis van Gaal's attack.
And one in, means one out, with Gary Neville suggesting Belgian whizkid Adnan Januzaj will be the unlucky player.
He told SkySports Monday Night Football: "I'd imagine Rooney would come in. If anything Januzaj could come out, due to the physicality of the game, but i actually think he did alright (against Chelsea)."
It would be unfortunate for Januzaj, who has struggled for starts this season, and performed well in the 1-1 draw, looking every inch an established player, rather than a youngster acclimatising to the league.
Neville went onto suggest that Angel di Maria could be played in a more central midfield role than he was against Chelsea, to help United out defensively, in terms of balance, and helping fit in attacking players like the returning Rooney.
It would be incredibly bold for van Gaal to select a front four of Mata, Rooney, Falcao and Van Persie, but even by just selecting three of them, it's hard to see where Januzaj would fit in.
His display against Chelsea however, at least offers hope that if he is left out, he will be called upon from the bench to change the game late on, and cause City trouble.