Di Maria has some good memories of facing the Belgian stopper and some bad ones.
Di Maria joined Manchester United on a British record transfer fee from Real Madridwhile Courtois joined up with Chelsea after three seasons on loan at Atletico Madrid.
With that in mind the two men have certainly faced each other a lot over the years.
Di Maria has a fairly decent record against the Belgian.
The United winger scored the winning goal when Real defeated Atletico in April 2013, a game in which fellow Manchester United newbie Radamel Falcao had opened the scoring for Los Colchoneros.
He also found the net in the Copa Del Rey against Courtois. Scoring in a 3-0 win back in February.
The two also faced off in this summer's World Cup. The Chelsea stopper consoling Di Maria after he went down injured, and injury that unfortunately ruled him out of the semi-final and final of the competition. The United winger suffered a thigh injury whilst shooting at the goal tended by the Belgian - leaving him on the floor in agony.
He also scored against Atleti in 2011, but Courtois has already been sent off in that fixture after misjudging a Di Maria through-ball and bringing down Karim Benzema.
Di Maria was also named man-of-the-match after Real defeated Atletico in the Champions League final last season. Although the Chelsea man has the bragging rights of La Liga to throw back at him.
So these two certainly know each other well. Expect Di Maria to try and defeat the Chelsea goalkeeper once again.