The two Premier League giants face off at Old Trafford, with a win for the Blues potentially moving them eight points clear at the top of the table, whilst United are looking to move into the top four.
Despite the likely absences of leading scorer Diego Costa - and his first-choice replacement Loic Remy - Chelsea are undoubtedly favourites for the tie, having yet been defeated this season, and arguably too strong for the fragile back-line that the Red Devils have been forced to line up with this campaign.
However, United are still at home, and history has taught everyone that they know how to win games - even in the most dire of circumstances.
Writing off the Red Devils, despite their poor start to the season - which has seen just three wins in eight games - would be unwise, and central defender Phil Jones - who is set to line up against the attacking talents the Blues possess - is confident that the West London club can be beaten.
Speaking to the official United website, the 22-year-old England international revealed that he expects Chelsea to put in a defensive display mirroring that shown at Old Trafford last season, despite Jose Mourinho’s men leading the Premier League scoring charts with 23 goals in just eight games.
Jones said: "They'll keep a good solid unit defensively and basically say 'Come and break us down’.
"We've got to find a way to do that. I think we really need to show them what we're about and how we can play. It's important to really express ourselves and not be afraid of playing against Chelsea.
"They're a good team but they're not unbeatable."
A win for United would close the gap on the league leaders, and it is vitally important that they clinch victory - with the Blues already 10 points clear of Louis van Gaal’s side. While Mourinho may line his side up to defend and leave with a draw, the Red Devils should fear the attacking talents on show - and it may be up to Jones to stop the likes of Eden Hazard, Willian and Cesc Fabregas from claiming three more points for the Blues.