However, leading goalscorer Diego Costa is set to miss the game thorough an injury carried over from international duty with Spain, whilst first-choice replacement Loic Remy pulled his groin in the process of scoring the opening goal in Tuesday night’s 6-0 victory over Maribor.
The absence of the two forwards could see Drogba given his first Premier League start of the season, and, although he opened his seasonal account with a penalty on Tuesday, the 36-year-old club legend has looked rusty and, quite simply, not good enough since his return to West London.
He is likely to struggle against the Red Devils on his current form, and Drogba’s past statistics against United make for even worse reading.
In his first spell at Stamford Bridge, Drogba netted just three goals in 19 games against the Manchester club. He struck the winner in the 2007 FA Cup Final, as well effectively handing Chelsea the title in April 2010 with an offside goal at Old Trafford. His final goal came in the 2011 Champions League, in an aggregate 3-1 loss to United in the last-16.
However, his most famous game against the Red Devils was arguably the worst.
The 2008 Champions League Final saw Drogba red carded for slapping Nemanja Vidic, making the Ivorian miss the penalty shoot-out - which United eventually won.
Despite his poor goalscoring record, the Blues have a positive win ratio when Drogba has featured against United. Eight wins and seven losses have been registered in the 19 games that the Ivorian has appeared in - and Chelsea will be looking to improve that record when the teams face off at Old Trafford.