Juventus slipped to a shock defeat away at Olympiakos, dealing them an unwelcome blow in their efforts to reach the Champions League knockout stages.
The Greek side won 1-0 through a goal from former Fulham midfielder Pajtim Kasami.
Impressive despite the surprise loss was midfield maestro Arturo Vidal, who did everything within his power to haul the Serie A champions towards a point.
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Vidal created four goalscoring opportunities, and won six tackles - but Juventus were unable to score a crucial equaliser.
A transfer target for Manchester United, Vidal's display was all the more encouraging considering his recent fitness problems.
Juventus had wasteful finishing to thank, with 18 shots on goal, but only five landing on target. Striker Alvaro Morata was the biggest culprit, with seven efforts on goal but only two testing the goalkeeper.
The Italians sit on three points after six games, equal with Malmo, while Olympiakos and Atletico Madrid share the lead with six each. The next game when Juventus host Olympiakos in Turin is a must-win for Vidal's side.
Potential Champions League elimination at the group stage would not bode well for their chances of keeping him, for they have not progressed past the last 16 during his time there. Another year of failure in Europe, could give Manchester United an edge in tempting him to Old Trafford, and even give Juventus a financial incentive to sell up.