The clubs face off at the Etihad Stadium on Saturday, with City looking to close the gap on league leaders Chelsea to two points, whilst Spurs could move into second place with three points.
A win is vital to both teams if they intend to stay in the race for the title, and a good performance could catalyse the campaign for either side, with neither club truly hitting top form as of yet. However, Spurs head into the fixture on the back of a dreadful record against City, with just one victory in eight Premier League fixtures, including an aggregate 11-1 defeat across the two games played last season.
The North Londoners went down 6-0 in Manchester in November 2013, before conceding five at White Hart Lane in January, and former Everton and Sunderland midfielder Kevin Kilbane believes that Spurs head coach Mauricio Pochettino would be wise to clear the players minds in the run up to the game.
Speaking to premierleague.com, Kilbane said: “I am sure that manager Mauricio Pochettino will try to eradicate those defeats from the players' minds but a majority of the players that played last season are still there, they know how City can hurt them and they have not started the season particularly well.
“The only way to get it out of your mind is by getting a victory but that's easier said than done because City are a real threat.”
Despite yet hitting top form, City still sit second in the Premier League table, and the goalscoring of Sergio Aguero, Stevan Jovetic and Edin Dzeko has claimed a number of points from games that City were outplayed, and Kilbane is convinced that Spurs must prevent City creating chances if they intend to steal a result from Manchester.
"The key will be how Spurs stop City creating chances,” he added.
“They have enough threat themselves going forward: Erik Lamela has been in decent form, Emmanuel Adebayor is a threat, Christian Eriksen is a good player, so it's how Tottenham Hotspur's defence copes with City's attack.
“If they can contain City, Spurs have got enough to hurt them on the counter-attack.”
Whilst playing a counter-attacking style is wise against the might of Manchester City, Spurs have yet to net a goal this season from a fast-break situation, although they have registered six shots from 10 total counter-attacks - the highest in the division. The stats prove that the Lilywhites are one of the best counter-attacking sides in the Premier League, but they will need an added precision to their finishing game if they intend to leave the Etihad with a share of the spoils.