The Reds face seven fixtures over the course of 21 days following this international break.
The Reds begin a fairly congested period with a trip to Loftus Road to take on Queens Park Rangers on Sunday, and it is the perfect time for the injured trio of Emre Can, Joe Allen and Daniel Sturridge to return to the side.
After QPR, Liverpool play the first of their two games against Real Madrid in this period. They also face Premier League games against Hull City, Newcastle United and Chelsea - along with a League Cup tie against Swansea City.
Marsh has said it is helpful to have as many players available as possible for this run of fixtures, a key period for the Reds both at home and in Europe.
He told the club's website: "We know it's a tough fixture list with the amount of games and the quality of the opposition so we know it's going to be tough, but the more players we have available the better.
"Our fitness programmes have been well documented. We try to recover the players as best we can to prepare for the game. We have a couple of days' recovery after the game and we work with the group of players for the next game.
"We do quite a lot of analysis with the players so we break them up into smaller groups and feed back in different ways."
The Reds will be worried about the injury that Dejan Lovren picked up on international duty, and will hope that Lazar Markovic comes through Serbia's European Championship qualifier against Albania.
Big players like Sturridge and Raheem Sterling could be key during this run of fixtures, and the Reds will rely on their squad depth as much as possible.