Luck completed 25 of 44 passes for 370 yards and three touchdowns, with one interception on the night as he saw his side hold on to win 33-28.
Hilton ended the game with nine receptions for a huge 223 yards and one touchdown, and he proved to be a major weapon for Luck once more.
J.J. Watt was as effective as ever at the line of scrimmage but he can't carry a team on his own, and the Texans didn't make enough use of the ball on offence.
Watt scored his third touchdown of the season as he returned a fumble 45 yards in the fourth-quarter, and finished with seven tackles - two of those being sacks, and also deflected three passes.
Fumbles late in the game on offence cost the Texans (3-3) the game as they needed a touchdown to win, but it was the Colts who ended victorious as they move to 4-2 for the season.