Aguero is the title winning if injury prone Argentine who adds a new dimension to City's side, while Rooney is United and England's captain who has a haul of medals in his own personal collection.
It seems remarkable Aguero is into his fourth season in the Premier League now, and over that time he and Rooney have made almost exactly the same number of appearances, Rooney edging it by two.
A comparison of their goal records across the seasons in England's top flight, shows Rooney to edge it - Scoring 59 to Aguero's 57.
Rooney cops a lot of flak for his at time under-par performances, but having a goal record he can boast of, to match Aguero, is reason for him to be boastful.
However a closer look at the figures, shows 24 of Rooney's strikes have come from penalties or free-kicks, compared to only 10 from the City forward.
And while their appearance totals are similar, the United captain has played 1,300 more minutes of Premier League football, with Aguero often substituted, or beginning on the bench, owing to his fitness issues.
Taking a slightly different approach therefore, looking at it from a minutes per goal angle, there is one winner.
|Team||Mins per goal||Mins per goal open play||Apps|
|Wayne Rooney||Man Utd||132.46||223.29||96|
|Sergio Agüero||Man City||114.35||138.68||94|
Especially so when looking at the comparison from a minutes per goal from open play perspective, with Manchester City striker Sergio Aguero netting on average 90 minutes more frequently than the England captain.
One area Rooney's record does stand up, is his creativity. He has made 26 assists compared with Aguero's 16 - averaging an assist 100 minutes more often than his City rival, but on chances created, Aguero holds his own.
|Team||Position||Mins per assist||Mins per key pass||Appearances|
|Wayne Rooney||Man Utd||FW||300.58||48.54||96|
|Sergio Agüero||Man City||FW||407.38||47.93||94|