Ozil has been ruled out for up to 12 weeks with a knee injury.
Arsenal have been dealt an injury blow from international duty already after Germany confirmed that Mesut Ozil will be out for three months after suffering an ankle ligament tear whilst in training for the world champions.
An official statement however claims that Ozil was already suffering with the problem on his arrival in Frankfurt, and assessment from famed Dr Hans-Wilhelm Muller-Wohlfahrt has confirmed the prognosis:
"The 25-year-old already complained on his arrival in Frankfurt on Tuesday about pain in his left knee. The MRI examination today at National Dr. Hans-Wilhelm Müller-Wohlfahrt in Munich revealed a partial rupture of the outer band of the left knee joint. The treatment is conservative, with six weeks of immobilization of the knee joint. Mesut Ozil is likely to be out for ten to twelve weeks."
In the immediate picture that rules Ozil out of Germany's upcoming fixtures against Poland and Republic of Ireland - while the DFB also confirmed he will be out of action for November's ties against Gibraltar and Spain.
But what about from an Arsenal perspective?
With Ozil expected to be out for 12 weeks, which games will he miss?
Arsenal will now not be able to call on Ozil for the several big clashes.
First of all their is the Champions League. Arsenal can expect to not see Ozil in action again until after the Champions League group stage. Their final game against Galatasaray on the 9th December comes at the very end of his rest period - it is safe to assume his Champions League football is over for the 2014 calendar year.
In the Premier League however there are only two games that really stand out from that period - Manchester United at The Emirates on the 22nd November and Liverpool at Anfield on the 21st December.
But some Arsenal fans, who have grown increasingly irritated at the lethargic performances of the German international, might even be glad to see the back of him for a little while.
His performance against Chelsea was perhaps his worst in an Arsenal shirt, although knowing now that he had a knee problem, could help explain his issues on the pitch on Sunday.
Regardless Ozil is a key member of the Arsenal team and there is little doubt he will be missed by the players until 2015.
Fans however will hope he comes back the Ozil they paid for last summer.