The game of the weekend sees plenty of intriguing ties between the two London giants.
As the only two Premier League clubs yet to taste defeat, the stakes are high for the London rivals as the table begins to take form.
Below we list four match ups set to take place on the pitch on Sunday, with the players involved likely to determine just where the points on offer will be heading come 4pm.
Per Mertesacker vs Diego Costa - The big German may end up with the unenviable responsibility of marking the Premier League's leading goalscorer, and will have to rely on all of his World Cup winning experience to keep Costa quiet. With the former Atletico man happy to engage in a physical confrontation, he would not have faced anyone quite as towering as the 6'6" Arsenal captain so far this season, but when on form, is more than capable of making a mockery of any defender.
John Terry vs Danny Welbeck - It is possible Gary Cahill will be given the task of keeping a watchful eye on Welbeck, given his own mobility, but if the former Manchester United striker is clever, he will be making runs behind the ageing John Terry at every opportunity. The Chelsea captain will have to display all of his canniness to keep tabs on the England forward, with his legs having nowhere near enough pace to deal with the 23-year-old.
Eden Hazard vs Calum Chambers - Young Calum Chambers may have played against Eden Hazard before in his career, but he would not have faced the Belgian in a game as big as Sunday's, a fixture set to be a huge test of the youngster's so-far mature and composed performances at his new club. Having flitted between central and fullback positions for Arsenal, Chambers will be playing from the right for the next few weeks after Mathieu Debuchy's injury, and will be up against last season's most dangerous winger, a player fully capable of putting the very best to the sword.
Cesc Fabregas vs Mesut Ozil - Though not in direct competition with each other, the former Arsenal playmaker is set to come up against the current star on account of Fabregas's slightly deeper position under Jose Mourinho. The creativity on offer from these two talented midfielders could well be the deciding influence on the game, with Ozil finding it harder to maintain a consistent threat while Fabregas has comfortably slotted back into the Premier League.