They do so after a 4,000 mile round trip to Russia to take on FK Krasnodar so will be hoping to have some fresh legs available for the game.
Two of those players will be Irish pair James McCarthy and Seamus Coleman. However, the latter may just fancy one more game off. Because the last time he faces Manchester United's new flying left-winger things did not go so well for him.
Coleman was making his debut for Everton after joining from Irish side Sligo Rovers for just £60,000. The game in question was a 2009 Europa League tie against Benfica, when he was tasked with stopping Angel Di Maria.
Di Maria was beginning to make a name for himself at the time and Benfica had a strong side which also contained the likes of David Luiz, Ramires and Fabio Coentrao.
It was always going to be a tough game for Everton. They had 11 first-team players unavailable but Coleman was torn apart by the impressive Di Maria in a game he would like to forget.
The Argentine did not find the score-sheet - but he did directly set-up four of the five goals scored that evening as Everton were taken to the cleaners.
Manchester United's club record signing will therefore be hoping that Coleman is in action tomorrow. Coleman will be hoping so too, so he can show Di Maria how far he has come in five years.